Objectives: To analyze the clinical characteristics and possible origin of the local outbreak of dengue fever in Dongguan City, Guangdong, China, in September 2010. Methods: The clinical data and serum samples of 30 patients with dengue fever were collected from the local hospitals. The patients infected with dengue virus (DENV) were confirmed by laboratory tests. And the epidemiological data were collected from site investigation and local Center for Disease Control and Prevention. Results: It was the first time to report the outbreak of Dengue fever in Dongguan city in recent 6 decades. The mean age of of 30 patients with dengue fever was 38(plus or minus)15.5 (range from 7 to 80) years. The main clinical manifestations were fever (100%), myalgia (76.7%), headache (63.3%), rash (56.7%), leucopenia (86.7%), low platelet count (66.7%), elevated alanine aminotransferase (67.9%) and aspartate aminotransferase (96.4%) etc. The first case was confirmed by laboratory diagnosis with a positive IgM and IgG antibody against DENV with similar symptoms described as above and he had returned back to Dongguan from a trip to Singapore and Malaysia on July 13, 2010, other cases gradually surfaced in the same community, from August 23, 2010 to September 18, 2010. The RT-PCR of the virus RNA and sequencing showed that it was a DENV-I strain virus and the E protein gene shares 99% homology to the strain identified in Malaysia in 2005. Conclusion: 30 patients identified in Dongguan City were typical dengue fever without clinical type of dengue hemorrhagic fever or dengue shock symptom. All of them were discharged from the local hospitals with good condition. And this local outbreak of dengue fever was initiated by an imported case traveling back from Singapore and Malaysia.
Zhang, H., Zhou, Y. P., Ding, H. J., Wang, W. J., Zhao, W., Hou, J. L., & Chen, X. G. (2011). PP-245 The clinical characteristics and epidemiological features of 30 dengue fever cases from a local outbreak in Dongguan City Southern China. International Journal of Infectious Diseases, 15, S113. https://doi.org/10.1016/s1201-9712(11)60395-0