PPARγ activators down-regulate the expression of PPARγ in 3T3-L1 adipocytes

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Transcriptional activation of PPARγ by the anti-diabetic compound troglitazone enhances the rate of 3T3-L1 adipocyte differentiation. In this study, we examined the effects of troglitazone, a specific PPARγ ligand, on the expression of PPARγ during and after 3T3-L1 adipocyte differentiation. Troglitazone treatment caused a significant decrease in PPARγ proteins and DNA binding activity. This reduction was associated with a similar decrease in transcription of PPARγ mRNA. These data suggest that in 3T3-L1 cells, the expression of PPARγ is auto-regulated. Copyright (C) 1999 Federation of European Biochemical Societies.




Camp, H. S., Whitton, A. L., & Tafuri, S. R. (1999). PPARγ activators down-regulate the expression of PPARγ in 3T3-L1 adipocytes. FEBS Letters, 447(2–3), 186–190. https://doi.org/10.1016/S0014-5793(99)00268-9

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