Progression from nonsevere sepsis---i.e., sepsis without organ failure or shock---to severe sepsis or shock among emergency department (ED) patients has been associated with significant mortality. Early recognition in the ED of those who progress to severe sepsis or shock during their hospital course may improve patient outcomes. We sought to identify clinical, demographic, and laboratory parameters that predict progression to severe sepsis, septic shock, or death within 96 h of ED triage among patients with initial presentation of nonsevere sepsis.
Holder, A. L., Gupta, N., Lulaj, E., Furgiuele, M., Hidalgo, I., Jones, M. P., … Birnbaum, A. (2016). Predictors of early progression to severe sepsis or shock among emergency department patients with nonsevere sepsis. International Journal of Emergency Medicine, 9(1), 1–11. https://doi.org/10.1186/s12245-016-0106-7