Predictors of no-reflow after percutaneous coronary intervention for culprit lesion with plaque rupture in infarct-related artery in patients with acute myocardial infarction

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Abstract

Background: We investigated the predictors of the no-reflow phenomenon after percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients with plaque rupture (PR). Methods: The study group comprised 112 AMI patients who underwent pre- and post-PCI intravascular ultrasound (IVUS) and stent implantation. Angiographic no-reflow was defined as TIMI flow grade 0, 1, and 2 after PCI. IVUS findings included multiple ruptured plaques (PRs separated by a >5-mm length of artery containing smooth lumen contours), thrombus (had a layered lobulated appearance, evidence of blood flow within the mass, and speckling or scintillation), and plaque prolapse (tissue extrusion through the stent struts). Results: Of 112 patients, no-reflow was observed in 17 patients (15.2%). High-sensitivity C-reactive protein (hs-CRP) was significantly higher (6.2 ± 6.0 mg/dl vs. 2.2 ± 2.9 mg/dl, p = 0.002) and baseline TIMI flow grade was significantly lower in no-reflow group (TIMI flow grade < 3: 59% vs. 18%, p < 0.001). Lesion site plaque plus media area was significantly greater (12.9 ± 2.6 mm 2 vs. 10.8 ± 4.2 mm 2 , p = 0.009), remodeling index was significantly higher (1.14 ± 0.17 vs. 1.03 ± 0.20, p = 0.031), and the presence of IVUS-detected thrombus (88% vs. 56%, p = 0.012), culprit lesion multiple PRs (71% vs. 37%, p = 0.009), and plaque prolapse (65% vs. 34%, p = 0.015) were significantly more common in no-reflow group. In the multivariate analysis, plaque prolapse (OR = 33.02; 95% CI 3.38-322.75, p = 0.003), hs-CRP (OR = 1.03; 95% CI 1.01-1.05, p = 0.013), and culprit lesion multiple PRs (OR = 15.73; 95% CI 1.61-153.46, p = 0.018) were independent predictors of post-PCI no-reflow in AMI patients with PR. Conclusions: Elevated hs-CRP and IVUS-detected multiple PRs and plaque prolapse are associated with no-reflow after PCI for PR-containing culprit lesion in infarct-related arteries in AMI patients. © 2009 Japanese College of Cardiology.

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Hong, Y. J., Jeong, M. H., Choi, Y. H., Ko, J. S., Lee, M. G., Kang, W. Y., … Kang, J. C. (2009). Predictors of no-reflow after percutaneous coronary intervention for culprit lesion with plaque rupture in infarct-related artery in patients with acute myocardial infarction. Journal of Cardiology, 54(1), 36–44. https://doi.org/10.1016/j.jjcc.2009.03.003

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