Preferential expression of Mdm2 oncogene during the development of neural crest and its derivatives in mouse early embryogenesis

10Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

The Mdm2 oncoprotein acts as the principal negative regulator of p53 activities and is essential for its control during mouse early development, at least before implantation. We analyzed Mdm2 expression between 7.5 and 9 days post-coitum (dpc) by whole-mount in situ hybridization and report here a novel expression pattern during neural crest development. At 7.5 dpc Mdm2 becomes preferentially expressed at the top of the neural folds. Between 8 and 9 dpc, this preferential expression is also observed in neural crest cells migrating from the closing brain towards craniofacial regions and the first three branchial arches. It persists in the craniofacial mesenchyme and the first branchial arch in 9 dpc embryos. Migrating neural crest cells in the tail region are also preferentially labeled at this stage. At day 9.5 Mdm2 becomes more ubiquitously expressed throughout the embryo as reported before. Copyright © 2001 Elsevier Science Ireland Ltd.

Cite

CITATION STYLE

APA

Daujat, S., Neel, H., & Piette, J. (2001). Preferential expression of Mdm2 oncogene during the development of neural crest and its derivatives in mouse early embryogenesis. Mechanisms of Development, 103(1–2), 163–165. https://doi.org/10.1016/S0925-4773(01)00339-2

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free