Background: Pre-existing heart disease is one of the major causes of maternal mortality and morbidity in pregnancy. Our aim is to investigate outcome of pregnancy in women with corrected tetralogy of Fallot (ToF). It is extremely important to find risk predictors which allow patients to be counseled appropriately when considering whether to become pregnant. Methods: The European Registry on Pregnancy and Heart disease is a prospective observational registry; 60 hospitals in 28 countries enrolled 1321 pregnant women between January 2007 and June 2011.There were 119 pregnant women with ToF. Results: Hospital admission during pregnancy was necessary in 18 patients (15%), mainly for obstetric reasons (50%). Heart failure occurred in only 4 pregnancies (3.4%) and one patient suffered from a ventricular tachycardia. There was one fetal death (0,8%). Caesarean section was performed in 39% of the patients, in only 2 patients this was for cardiac reasons. Mean pregnancy duration was 38 weeks and birth weight was 3,0 kg, the APGAR score lower than 7 in 8 children (6,7%) and only 8,8 % were small for gestational age. Conclusions: In the European registry on pregnancy and heart disease a low event rate was found in patients with Tetralogy of Fallot. Pregnancy was generally uncomplicated from the cardiac point of view with low morbidity rate and both maternal and fetal survival was excellent.
Ruys, P. T. E., Roos-Hesselink, J., Webb, G., Johnson, M. R., & Hall, R. (2012). PREGNANCY IN WOMEN WITH CORRECTED TETRALOGY OF FALLOT: THE EUROPEAN REGISTRY ON PREGNANCY AND HEART DISEASE. Journal of the American College of Cardiology, 59(13), E841. https://doi.org/10.1016/s0735-1097(12)60842-0