Cystic fibrosis (CF) is one of the most common fatal autosomal recessive disorders in the Caucasian population caused by mutations of gene for the cystic fibrosis transmembrane conductance regulator (CFTR). New experimental therapeutic strategies for CF propose a diet supplementation to affect the plasma membrane fluidity and to modulate amplified inflammatory response. The objective of this study was to evaluate the efficacy of 5-methyltetrahydrofolate (5-MTHF) and vitamin B12 supplementation for ameliorating cell plasma membrane features in pediatric patients with cystic fibrosis.
Scambi, C., De Franceschi, L., Guarini, P., Poli, F., Siciliano, A., Pattini, P., … Bambara, L. M. (2009). Preliminary evidence for cell membrane amelioration in children with Cystic fibrosis by 5-MTHF and vitamin B12 supplementation: A single arm trial. PLoS ONE, 4(3). https://doi.org/10.1371/journal.pone.0004782