The incidence both of first attacks of rheumatic fever and of recurrences of the disease in patients who have had one or more attacks can be greatly reduced. Early adequate treatment of streptococcal infections definitely can reduce the incidence of rheumatic fever. When rheumatic fever does occur, following the eradication of the group A streptococcus by an adequate course of penicillin therapy, recurrent attacks can be prevented in most instances by the continuous administration of any one of several antibacterial drugs. It is to be hoped that ultimately a more biologic method of preventing streptococcal infections and acute rheumatic fever will be available. However, until this does occur, the current available methods of treating and preventing streptococcal infection can greatly reduce the incidence of rheumatic fever and of recurrences of the disease. © 1958.
Wood, H. F. (1958). Prevention of rheumatic fever. The American Journal of Cardiology, 1(4), 456–463. https://doi.org/10.1016/0002-9149(58)90115-2