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Proteins are the working horse of the cellular machinery. They are responsible for diverse functions ranging from molecular motors to signaling. They catalyze reactions, transport, form the building blocks of viral capsids, traverse the membranes to yield regulated channels, and transmit the information from the DNA to the RNA. They synthesize new molecules, and they are responsible for their degradation. Proteins are the vehicles of the immune response and of viral entry into cells. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures (e.g., refs 1-6). A practical way to predict protein function is through identification of the binding partners. Since the vast majority of protein chores in living cells are mediated by protein-protein interactions, if the function of at least one of the components with which the protein interacts is identified, it is expected to facilitate its functional and pathway assignment.




Keskin, O., Gursoy, A., Ma, B., & Nussinov, R. (2008, April). Principles of protein-protein interactions: What are the preferred ways for proteins to interact? Chemical Reviews. https://doi.org/10.1021/cr040409x

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