Production, sterilisation and storage of biodegradable electrospun PLGA membranes for delivery of limbal stem cells to the cornea

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Abstract

Our aim was to produce, sterilize and store a synthetic, rapidly biodegrading membrane for cultured limbal stem cell transplantation. Membranes were electrospun from Poly(D, L-lactide-co-glycolide) with a 50:50 ratio of lactide and glycolide comparing 44 kg/mol and 153 kg/mol molecular weights (MW) and sterilized with y-irradiation and stored for up to a year at a range of temperatures. Cells attached well on both MW membranes. The lower MW degraded faster than the higher MW membranes. y-irradiation accelerated membrane breakdown when wet but sterilised membranes could be stored dry for at least a year at -20°C. © 2013 The Authors.

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Sefat, F., McKean, R., Deshpande, P., Ramachandran, C., Hill, C. J., Sangwan, V. S., … MacNeil, S. (2013). Production, sterilisation and storage of biodegradable electrospun PLGA membranes for delivery of limbal stem cells to the cornea. In Procedia Engineering (Vol. 59, pp. 101–116). Elsevier Ltd. https://doi.org/10.1016/j.proeng.2013.05.099

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