The use of the immunosuppressant sirolimus in kidney transplantation has been made problematic by the frequent occurrence of various side effects, including paradoxical inflammatory manifestations, the pathophysiology of which has remained elusive.
Buron, F., Malvezzi, P., Villar, E., Chauvet, C., Janbon, B., Denis, L., … Thaunat, O. (2013). Profiling Sirolimus-Induced Inflammatory Syndrome: A Prospective Tricentric Observational Study. PLoS ONE, 8(1). https://doi.org/10.1371/journal.pone.0053078