Prognostic value of bone scan index as an imaging biomarker in metastatic prostate cancer: a meta-analysis

  • Li D
  • Lv H
  • Hao X
  • et al.
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Abstract

// Dongyang Li 1, * , Hang Lv 2, * , Xuanyu Hao 3 , Yudi Dong 4 , Huixu Dai 5 and Yongsheng Song 1 1 Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China 2 Department of Urology, Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University, Shenyang, Liaoning 110042, P.R. China 3 Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China 4 Department of Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China 5 Department of Clinical Epidemiology and Evidence-based Medicine, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China * These authors contributed equally to this work Correspondence to: Yongsheng Song, email: sys-urology@outlook.com Keywords: metastatic prostate cancer, bone scan index, prognosis, survival, meta-analysis Received: March 26, 2017      Accepted: June 30, 2017      Published: July 29, 2017 ABSTRACT Background: The prognostic value of the bone scan index (BSI) in metastatic prostate cancer (mPCa) remained controversial. Therefore, we performed a meta-analysis to determine the predictive value of BSI and survival in patients with mPCa. Materials and Methods: A literature search was performed in PubMed, Embase, Web of Science and Cochrane library databases. Hazard ratios (HRs), concordance indices (C-indices) were extracted to estimate the relationship between BSI and survival in patients with mPCa. Subgroup analyses were conducted on different types of mPCa, ethnics, cut-off values and sample sizes. Results: 14 high quality studies involving 1295 patients with mPCa were included in this meta-analysis. The pooled results indicated that high basline BSI and elevated BSI change on treatment (ΔBSI) were significantly predictive of poor overall survial (HR = 1.29, P < 0.001; HR = 1.27, P < 0.001, respectively). Baseline BSI was also significantly related to cancer specific survival (HR = 1.65, P = 0.019) and prostate specific antigen recurrence survival (HR = 2.26, P < 0.001). Subgroup analysis supported main results. Moreover, BSI could increase the C-indices of predictive models. Conclusions: Baseline BSI and ΔBSI may be beneficial to mPCa prognosis in clinical monitor and treatment. Further high quality studies with larger sample size are required in the future.

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Li, D., Lv, H., Hao, X., Dong, Y., Dai, H., & Song, Y. (2017). Prognostic value of bone scan index as an imaging biomarker in metastatic prostate cancer: a meta-analysis. Oncotarget, 8(48). https://doi.org/10.18632/oncotarget.19680

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