Background . The pro- and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective . The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF- α ) in H. pylori -infected patients and healthy controls and to understand their association with H. pylori infection and disease severity. Results . The expression levels of IL-17 and IL-23 were significantly higher in H. pylori- infected patients. The expression of IL-21 was also higher in H. pylori- positive patients but there was no significant association with infection. IL-17 expression showed a significant increase with the severity of chronic gastritis. Conclusion . The proinflammatory cytokine, IL-17, shows a significant association with H. pylori infection and disease severity in a Sri Lankan dyspeptic patient population.
Arachchi, P. S., Fernando, N., Weerasekera, M. M., Senevirathna, B., Weerasekera, D. D., & Gunasekara, C. P. (2017). Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity . Gastroenterology Research and Practice, 2017, 1–7. https://doi.org/10.1155/2017/6265150