Prospective associations and population impact of sweet beverage intake and type 2 diabetes, and effects of substitutions with alternative beverages Abbreviations %TEI Per cent contribution to total energy intake ASB Artificially sweetened beverages EPIC

Abstract

Aims/hypothesis This study aimed to evaluate the association of types of sugar-sweetened beverages (SSB) (soft drinks, sweetened-milk beverages, sweetened tea/coffee), artificially sweetened beverages (ASB) and fruit juice with incident type 2 diabetes and determine the effects of substituting non-SSB for SSB and the population-attributable fraction of type 2 di-abetes due to total sweet beverages. Methods Beverage consumption of 25,639 UK-resident adults without diabetes at baseline (1993–1997) in the Euro-pean Prospective Investigation into Cancer and Nutrition (EP-IC)-Norfolk study was assessed using 7-day food diaries. Dur-ing 10.8 years of follow-up 847 incident type 2 diabetes cases were verified. Results In adjusted Cox regression analyses there were posi-tive associations (HR [95% CI] per serving/day]) for soft drinks 1.21 (1.05, 1.39), sweetened-milk beverages 1.22 (1.05, 1.43) and ASB 1.22 (1.11, 1.33), but not for sweetened tea/coffee 0.98 (0.94, 1.02) or fruit juice 1.01 (0.88, 1.15). Further adjustment for adiposity attenuated the association of ASB, HR 1.06 (0.93, 1.20). There was a positive dose– response relationship with total sweet beverages: HR per 5% energy 1.18 (1.11, 1.26). Substituting ASB for any SSB did not reduce the incidence in analyses accounting for energy intake and adiposity. Substituting one serving/day of water or unsweetened tea/coffee for soft drinks and for sweetened-milk beverages reduced the incidence by 14%–25%. If sweet beverage consumers reduced intake to below 2% energy, 15% of incident diabetes might be prevented. Conclusions/interpretation The consumption of soft drinks, sweetened-milk beverages and energy from total sweet bever-ages was associated with higher type 2 diabetes risk indepen-dently of adiposity. Water or unsweetened tea/coffee appear to be suitable alternatives to SSB for diabetes prevention. These findings support the implementation of population-based in-terventions to reduce SSB consumption and increase the con-sumption of suitable alternatives.