The protective effect of Hypericum origanifolium in experimental renal ischemia/reperfusion injury in rats

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Hypericum origanifolium&nbsp;leaf extract (HOE) is a medicinal plant extract containing many polyphenolic compounds. Polyphenolic compounds have high antioxidant potential. Reactive oxygen metabolites (ROMs) play a role in the pathogenesis of ischemia/reperfusion injury (I/R) in the kidney. This study was designed to determine the possible protective effect of HOE on renal I/R injury. Twenty four adult female Wistar albino rats were evaluated in three groups. Group 1 (Control), group 2 (renal I/R injury+Saline), and group 3 (renal I/R injury+HOE 50 mg/kg) were designed to evaluate the effects of HOE in renal I/R injury on histopathological examinations. The&nbsp;malondialdehyde&nbsp;(MDA) levels,&nbsp;superoxide dismutase (SOD) and&nbsp;catalase(CAT) activities were determined.&nbsp;Plasma blood urea nitrogen (BUN), creatinine (Cr), uric acid (UAC), SGOT (alanine aminotransferase, ALT), SGPT (serum aspartat aminotransferase, AST) and lactate dehydraogenase (LDH) levels were measured. HOE&nbsp;treatments in renal ischemia-reperfusion decreased MDA in kidney and liver. SOD and CAT activities were increased with&nbsp;HOE&nbsp;treatment in kidney and liver. When all groups were compared histopathologically in kidney, HOE administration improved I/R-induced damages such as hyaline cast, tubular dilatation and parenchymal hemorrhagia. The plasma BUN values were increased in I/R group when compared with control; on the other hand after HOE administration, the BUN values decreased, but not significantly. The Cr, UAC, SGOT, SGPT and LDH levels increased in I/R group, but decreased after HOE administration when compared with I/R group.&nbsp;The findings imply that ROMs play a causal role in I/R-induced renal injury and HOE exerts renoprotective effects probably by the radical scavenging and antioxidant activities<br /><br />\t&nbsp;<br /><br />\tKey words:&nbsp;Hypericum origanifolium,&nbsp;renal ischemia/reperfusion, rat, antioxidant.




SENTURK, H. (2014). The protective effect of Hypericum origanifolium in experimental renal ischemia/reperfusion injury in rats. African Journal of Pharmacy and Pharmacology, 7(33), 2306–2312.

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