Cytosolic phospholipase A2α (cPLA2α) plays an important role in arachidonate pathway. To investigate the contribution of cPLA2α to autoimmune diabetes, we established non-obese diabetic (NOD) mouse, an excellent model for human type 1 diabetes, deficient in cPLA2α. These mice showed severe insulitis and a higher incidence of diabetes. In their macrophages, decreased prostaglandin E 2 (PGE2) induced by cPLA2α deficiency, and the increase in production of tumor necrosis factor (TNF)-α were observed. These results suggested that cPLA2α plays a protective role in progression of insulitis and development of autoimmune diabetes by suppression of TNF-α production from macrophages. © 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
Oikawa, Y., Yamato, E., Tashiro, F., Yamamoto, M., Uozumi, N., Shimada, A., … Miyazaki, J. (2005). Protective role for cytosolic phospholipase A2α in autoimmune diabetes of mice. FEBS Letters, 579(18), 3975–3978. https://doi.org/10.1016/j.febslet.2005.06.024