Protein carbonylation in human diseases

627Citations
Citations of this article
266Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Oxidative modifications of enzymes and structural proteins play a significant role in the aetiology and/or progression of several human diseases. Protein carbonyl content is the most general and well-used biomarker of severe oxidative protein damage. Human diseases associated with protein carbonylation include Alzheimer's disease, chronic lung disease, chronic renal failure, diabetes and sepsis. Rapid recent progress in the identification of carbonylated proteins should provide new diagnostic (possibly pre-symptomatic) biomarkers for oxidative damage, and yield basic information to aid the establishment an efficacious antioxidant therapy.

Cite

CITATION STYLE

APA

Dalle-Donne, I., Giustarini, D., Colombo, R., Rossi, R., & Milzani, A. (2003, April 1). Protein carbonylation in human diseases. Trends in Molecular Medicine. Elsevier Ltd. https://doi.org/10.1016/S1471-4914(03)00031-5

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free