Recent advances in sequencing techniques, applied to the study of microbial communities, have provided compelling evidence that the mammalian intestinal tract harbors a complex microbial community whose composition is a critical determinant of host health in the context of metabolism and inflammation. Given that an imbalanced gut microbiota often arises from a sustained increase in abundance of the phylum Proteobacteria, the natural human gut flora normally contains only a minor proportion of this phylum. Here, we review studies that explored the association between an abnormal expansion of Proteobacteria and a compromised ability to maintain a balanced gut microbial community. We also propose that an increased prevalence of Proteobacteria is a potential diagnostic signature of dysbiosis and risk of disease.
Shin, N. R., Whon, T. W., & Bae, J. W. (2015, September 1). Proteobacteria: Microbial signature of dysbiosis in gut microbiota. Trends in Biotechnology. Elsevier Ltd. https://doi.org/10.1016/j.tibtech.2015.06.011