Trypanosoma cruzi is a Kinetoplastid parasite of humans and is the cause of Chagas disease, a potentially lethal condition affecting the cardiovascular, gastrointestinal, and nervous systems of the human host. Constraint-based modeling has emerged in the last decade as a useful approach to integrating genomic and other high-throughput data sets with more traditional, experimental data acquired through decades of research and published in the literature.
Roberts, S. B., Robichaux, J. L., Chavali, A. K., Manque, P. A., Lee, V., Lara, A. M., … Buck, G. A. (2009). Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi. BMC Systems Biology, 3. https://doi.org/10.1186/1752-0509-3-52