Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation

151Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

Abstract

Growth factors have been implicated in thymocyte development, but mutants lacking cytokines, or their receptors, have failed to reveal essential roles for growth/differentiation factors in the thymus. Mutations in the receptor tyrosine kinase c-kit and the common cytokine receptor γ chain (γ(c)) reduce cellularity, but are permissive for thymocyte development. We now report that thymocyte development is completely abrogated in mice lacking both c-kit and γ(c) (c-kit-γ(c)-). Thymic hypocellularity is so severe that the T cell receptor repertoire fails to form except for monoclonal or oligoclonal β chain DJ rearrangements. B lymphopoiesis is only mildly reduced in c-kit-γ(c)- as compared with c-kit+γ(c)- mice, and hematological values are identical comparing c-kit-deficient and c-kit-γ(c)- mice. These experiments reveal essential, overlapping, and synergistic functions for two distinct signaling pathways, one utilizing c-kit and the other cytokine receptor γ(c) complexes coupling to Janus kinases and signal transducers and activators of transcription.

Cite

CITATION STYLE

APA

Rodewald, H. R., Ogawa, M., Haller, C., Waskow, C., & DiSanto, J. P. (1997). Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation. Immunity, 6(3), 265–272. https://doi.org/10.1016/S1074-7613(00)80329-5

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free