Pulmonary langerhans cell histiocytosis with recurrent pneumothorax

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A 20-year-old woman with recurrent right pneumothorax was admitted to our hospital. A thoracoscopic bullectomy and lung biopsy was performed under general anesthesia. According to the histopathologic findings of permanent sections, a tissue specimen of diffuse lung disease revealed eosinophil infiltration and the presence of fibroblasts. Immunohistochemical stain showed S-100 protein-positive, as well as cluster of differentiation-68-positive large Langerhans cells. As a result, pulmonary Langerhans cell histiocytosis was diagnosed. The patient had an uncomplicated postoperative course and was discharged from the hospital on postoperative day 5. No recurrence was observed during the 6-month observation period. © 2011 The Society of Thoracic Surgeons.




Muramatsu, T., Shimamura, M., Furuichi, M., Nishii, T., Takeshita, S., & Shiono, M. (2011). Pulmonary langerhans cell histiocytosis with recurrent pneumothorax. Annals of Thoracic Surgery, 91(6). https://doi.org/10.1016/j.athoracsur.2011.01.038

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