Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

694Citations
Citations of this article
168Readers
Mendeley users who have this article in their library.

Abstract

Puma encodes a BH3-only protein that is induced by the p53 tumor suppressor and other apoptotic stimuli. To assess its physiological role in apoptosis, we generated Puma knockout mice by gene targeting. Here we report that Puma is essential for hematopoietic cell death triggered by ionizing radiation (IR), deregulated c-Myc expression, and cytokine withdrawal. Puma is also required for IR-induced death throughout the developing nervous system and accounts for nearly all of the apoptotic activity attributed to p53 under these conditions. These findings establish Puma as a principal mediator of cell death in response to diverse apoptotic signals, implicating Puma as a likely tumor suppressor.

Cite

CITATION STYLE

APA

Jeffers, J. R., Parganas, E., Lee, Y., Yang, C., Wang, J. L., Brennan, J., … Zambetti, G. P. (2003). Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell, 4(4), 321–328. https://doi.org/10.1016/S1535-6108(03)00244-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free