The Q705K and F359L Single-Nucleotide Polymorphisms of NOD-Like Receptor Signaling Pathway: Association with Chronic Pancreatitis, Pancreatic Cancer, and Periodontitis

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Abstract

The aim of this study was to establish the correlation between the<br />occurrence of Q705K and F359L polymorphisms in patients diagnosed with<br />pancreatic diseases and periodontal conditions of various degrees of<br />severity. The above-mentioned genetic markers were assessed in patients<br />with pancreatic cancer (n = 18) and chronic pancreatitis (n = 39) as<br />well as in a healthy control group (n = 115). The established inclusion<br />criteria were the following: Caucasian descent, non-smoking, and age<br />range 20-80, with different levels of periodontitis activity according<br />to S. Offenbacher's scale. The genotyping reactions were performed by<br />means of an RT-PCR with the use of TaqMan(A (R)) genotyping assay.<br />Results of the study revealed that the state of periodontium was<br />significantly worse in patients with chronic pancreatitis. The Q705K and<br />F359L polymorphisms were associated with more advanced cases of<br />periodontitis measured by clinical attachment level, whereas the Q705K<br />was associated with intensified bleeding index. Furthermore, the F359L<br />single-nucleotide polymorphism was significantly higher in the group<br />with chronic pancreatitis (p < 0.0001; OR = 6.8571). Whereas, the<br />prevalence of Q705K polymorphism was higher in the group of pancreatic<br />cancer (p = 0.107; OR = 3.3939). This study suggests that the<br />exaggerated inflammatory response provoked by Q705K and F359L might be<br />the common denominator for periodontitis, pancreatic cancer, and chronic<br />pancreatitis. These findings might constitute the basis for a new<br />diagnostic and therapeutic approach.

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APA

Miskiewicz, A., Szparecki, G., Durlik, M., Rydzewska, G., Ziobrowski, I., & Górska, R. (2015). The Q705K and F359L Single-Nucleotide Polymorphisms of NOD-Like Receptor Signaling Pathway: Association with Chronic Pancreatitis, Pancreatic Cancer, and Periodontitis. Archivum Immunologiae et Therapiae Experimentalis, 63(6), 485–494. https://doi.org/10.1007/s00005-015-0355-9

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