RAGE-mediated inflammation, type 2 diabetes, and diabetic vascular complication

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Abstract

Obesity is associated with inflammation and type 2 diabetes. Innate immune system comprised of cellular and molecular components plays an important role in the inflammatory reactions. Immune cells like macrophages and their cell surface pattern-recognition receptors (PRRs) are representative for innate immunity promoting inflammatory reactions. The receptor for advanced glycation end-products (RAGE) is a member of PRRs and a proinflammatory molecular device that mediates danger signals to the body. The expression of RAGE is observed in adipocytes as well as immune cells, endothelial cells, and pancreatic β cells under certain conditions. It has been reported that RAGE is implicated in adipocyte hypertrophy and insulin resistance. RAGE-mediated regulation of adiposity and inflammation may attribute to type 2 diabetes and diabetic vascular complications. © 2013 Yamamoto and Yamamoto.

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Yamamoto, Y., & Yamamoto, H. (2013). RAGE-mediated inflammation, type 2 diabetes, and diabetic vascular complication. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2013.00105

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