Ras-deregulated cells require reactive oxygen species for proliferation. They survive the resultant proteotoxic stress by maintaining sufficient levels of reduced glutathione and optimally functioning stress response machinery. In this issue of Cancer Cell, De Raedt et al. identify a novel strategy that utilizes this dependency to cause cell death. © 2011 Elsevier Inc.
Xu, W., Trepel, J., & Neckers, L. (2011, September). Ras, ROS and proteotoxic stress: A delicate balance. Cancer Cell. https://doi.org/10.1016/j.ccr.2011.08.020