Rat model of cardiopulmonary bypass for deep hypothermic circulatory arrest

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Large animal cardiopulmonary bypass (CPB) models have disadvantages, such as cost, lack of methods for assessment of neurocognitive function, and difficulties with long-term recovery. As a result, rodent models have been developed. 1-4 Previous rodent models have certain drawbacks, including irrelevance to human flows used clinically. We established a clinically relevant model of CPB with deep hypothermic circulatory arrest (DHCA) in the rat. Our CPB circuit has several novel features, including a small priming volume, active cooling/rewarming processes, vacuum-assisted venous drainage, peripheral cannulation without thoracotomy or sternotomy, and an accurate means of monitoring peripheral tissue oxygenation. This small animal model provides a simple experimental system that could be used in future studies that use CPB and DHCA. © 2011 by The American Association for Thoracic Surgery.




Waterbury, T., Clark, T. J., Niles, S., & Farivar, R. S. (2011). Rat model of cardiopulmonary bypass for deep hypothermic circulatory arrest. Journal of Thoracic and Cardiovascular Surgery, 141(6), 1549–1551. https://doi.org/10.1016/j.jtcvs.2011.01.062

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