Reactive oxygen species downregulate catalase expression via methylation of a CpG Island in the Oct-1 promoter

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Abstract

Reactive oxygen species (ROS) caused oxidative stress plays a key role in carcinogenesis. The POU domain transcription factor Oct-1 and catalase is closely associated with ROS. However, a correlation between these two key proteins has not been demonstrated before. In this report, we show that Oct-1 acts as an activator of catalase, by binding to the catalase promoter in hepatocellular carcinoma (HCC) cell lines. In addition, we suggest that Oct-1 is downregulated by ROS via CpG island methylation in its promoter. These findings contribute to a better understanding of the epigenetic changes induced by ROS in the process of carcinogenesis. © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Quan, X., Lim, S. O., & Jung, G. (2011). Reactive oxygen species downregulate catalase expression via methylation of a CpG Island in the Oct-1 promoter. FEBS Letters, 585(21), 3436–3441. https://doi.org/10.1016/j.febslet.2011.09.035

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