Recent advances for the direct introduction of the CF 2 Me moiety

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Fluorine-containing molecules are compounds of interest in materials as well as in pharmaceutical and agrochemical industries. Therefore, developments in that research field are tremendous and a special focus was dedicated to the design and the study of emergent fluorinated groups. In particular, the CF 2 Me residue is attractive as it could be used for example as a bioisostere of the methoxy group. Despite the clear asset that represents this fluorinated moiety and in complement to the traditional approaches used to construct the CF 2 Me residue from existing functional groups, the quest for direct methodologies for the 1,1-difluoroethylation reaction of molecules has triggered a strong interest from the scientific community. This Mini-review will focus on the recent advances toward the design of reagents and their applications for the direct 1,1-difluoroethylation of various classes of compounds.




Carbonnel, E., Poisson, T., Jubault, P., Pannecoucke, X., & Besset, T. (2019). Recent advances for the direct introduction of the CF 2 Me moiety. Frontiers in Chemistry. Frontiers Media S.A.

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