Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease

5Citations
Citations of this article
33Readers
Mendeley users who have this article in their library.

Abstract

Protein-tyrosine phosphatases (PTPs) remove phosphate groups from tyrosine residues, and thereby propagate or inhibit signal transduction, and hence influence cellular processes such as cell proliferation and differentiation. The importance of tightly controlled PTP activity is reflected by the numerous mechanisms employed by the cell to control PTP activity, including a variety of post-translational modifications, and restricted subcellular localization. This review highlights the strides made in the last decade and discusses the important role of PTPs in key aspects of embryonic development: the regulation of stem cell self-renewal and differentiation, gastrulation and somitogenesis during early embryonic development, osteogenesis, and angiogenesis. The tentative importance of PTPs in these processes is highlighted by the diseases that present upon aberrant activity.

Cite

CITATION STYLE

APA

Hale, A. J., ter Steege, E., & den Hertog, J. (2017, August 15). Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease. Developmental Biology. Elsevier Inc. https://doi.org/10.1016/j.ydbio.2017.03.023

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free