Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design

39Citations
Citations of this article
51Readers
Mendeley users who have this article in their library.

Abstract

The discovery of the Campylobacter jejuni N-linked glycosylation system combined with its functional expression in Escherichia coli marked the dawn of a new era in glycoengineering. The process, termed protein glycan coupling technology (PGCT), has, in particular, been applied to the development of glycoconjugate vaccines. In this review, we highlight recent technical developments in this area, including the first structural determination of the coupling enzyme PglB, the use of glycotags for optimal glycan attachment and the possible applications of other glycosylation systems and how these may improve and extend PGCT.

Cite

CITATION STYLE

APA

Terra, V. S., Mills, D. C., Yates, L. E., Abouelhadid, S., Cuccui, J., & Wren, B. W. (2012, July). Recent developments in bacterial protein glycan coupling technology and glycoconjugate vaccine design. Journal of Medical Microbiology. https://doi.org/10.1099/jmm.0.039438-0

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free