We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.
Sakuma, S., Saya, H., Tada, M., Nakao, M., Fujiwara, T., Roth, J. A., … Hiroshi, A. (1996). Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. FEBS Letters, 398(2–3), 165–169. https://doi.org/10.1016/S0014-5793(96)01234-3