Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

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We have previously reported on radiation-induction of ptk-3 in rat astr ocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.




Sakuma, S., Saya, H., Tada, M., Nakao, M., Fujiwara, T., Roth, J. A., … Hiroshi, A. (1996). Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. FEBS Letters, 398(2–3), 165–169.

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