Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data

45Citations
Citations of this article
245Readers
Mendeley users who have this article in their library.

Abstract

Analysis of Hi-C data has shown that the genome can be divided into twocompartments called A/B compartments. These compartments are cell-type specific and are associated with open and closed chromatin. We show that A/B compartments can reliably be estimated using epigenetic data from several different platforms: the Illumina 450k DNA methylation microarray, DNase hypersensitivity sequencing, single-cell ATAC sequencing and single-cell whole-genome bisulfite sequencing. We do this by exploiting that the structure of long-range correlations differs between open and closed compartments. This work makes A/B compartment assignment readily available in a wide variety of cell types, including many human cancers.

Cite

CITATION STYLE

APA

Fortin, J. P., & Hansen, K. D. (2015). Reconstructing A/B compartments as revealed by Hi-C using long-range correlations in epigenetic data. Genome Biology, 16(1). https://doi.org/10.1186/s13059-015-0741-y

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free