Redox responses in patients with sepsis: High correlation of Thioredoxin-1 and macrophage migration inhibitory factor plasma levels

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Abstract

Background . Redox active substances (e.g., Thioredoxin-1, Macrophage Migration Inhibitory Factor) seem to be central hubs in the septic inflammatory process. Materials and Methods . Blood samples from patients with severe sepsis or septic shock ( n=15 ) were collected at the time of sepsis diagnosis ( t 0), and 24 ( t 24) and 48 ( t 48) hours later; samples from healthy volunteers ( n=18 ) were collected once; samples from postoperative patients ( n=28 ) were taken one time immediately after surgery. In all patients, we measured plasma levels of IL-6, TRX1 and MIF. Results . The plasma levels of MIF and TRX1 were significantly elevated in patients with severe sepsis or septic shock. Furthermore, TRX1 and MIF plasma levels showed a strong correlation ( t 0: rsp=0.720,ρ=0.698/t24 : rsp=0.771,ρ=0.949 ). Conclusions . Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response.

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Brenner, T., Rosenhagen, C., Steppan, J., Lichtenstern, C., Weitz, J., Bruckner, T., … Hofer, S. (2010). Redox responses in patients with sepsis: High correlation of Thioredoxin-1 and macrophage migration inhibitory factor plasma levels. Mediators of Inflammation, 2010. https://doi.org/10.1155/2010/985614

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