Activation of E2F transcription factors is thought to drive the expression of genes essential for the transition of cells from G1 to S phase and for the initiation of DNA replication. However, this textbook view of E2Fs is increasingly under challenge. Here we discuss an alternative model for how E2Fs may work. © 2006 Elsevier Inc. All rights reserved.
Rowland, B. D., & Bernards, R. (2006, December 1). Re-Evaluating Cell-Cycle Regulation by E2Fs. Cell. https://doi.org/10.1016/j.cell.2006.11.019