Regression method to estimate provisional TLV/WEEL-equivalents for non- carcinogens

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Abstract

There is a huge and changing number of chemicals in commerce for which workplace exposure criteria have not been assigned. Assigning an exposure criterion by an expert committee is resource-intensive - not soon available for the large majority of chemicals in current use. In the absence of assigned criteria, we have provided a regression method to estimate a first- screen estimate of a 'TLV/WEEL-equivalent' inhalation time-weighted average exposure criterion for a pure chemical (or chemical group) from a measure of a non-stochastic toxic exposure to elicit a chronic or sub-chronic health effect, known as a lowest observable adverse effect level (LOAEL) or a (highest) no observable adverse effect level (NOAEL). Results are presented for six data sets for which both a threshold limit value (TLV) or workplace environmental exposure level (WEEL) exposure criterion is presently assigned, and a LOAEL or NOAEL measure of toxic health effect was available from the United States Environmental Protection Agency Integrated Risk Information System data base. The results can be applied as a first estimate of exposure to substances for which no TLV or WEEL (TLV/WEEL) exists, and also serve as a mechanism for identifying substances for potential re-evaluation of their exposure limit, based on their relative position about the prediction models. (C) 2000 British Occupational Hygiene Society.

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APA

Whaley, D. A., Attfield, M. D., Bedillion, E. J., Walter, K. M., & Yi, Q. (2000). Regression method to estimate provisional TLV/WEEL-equivalents for non- carcinogens. Annals of Occupational Hygiene, 44(5), 361–374. https://doi.org/10.1016/S0003-4878(99)00108-8

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