Regulation of CSF1 promoter by the SWI/SNF-like BAF complex

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Abstract

The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF complex and the BAF-dependent activation of the promoter. Furthermore, the activation of the CSF1 promoter requires Z-DNA-forming sequences that are converted to Z-DNA structure upon activation by the BAF complex. The BAF complex facilitates Z-DNA formation in a nucleosomal template in vitro. We propose a model in which the BAF complex promotes Z-DNA formation which, in turn, stabilizes the open chromatin structure at the CSF1 promoter.

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Liu, R., Liu, H., Chen, X., Kirby, M., Brown, P. O., & Zhao, K. (2001). Regulation of CSF1 promoter by the SWI/SNF-like BAF complex. Cell, 106(3), 309–318. https://doi.org/10.1016/S0092-8674(01)00446-9

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