Regulation of the T-independent humoral response by TACI

388Citations
Citations of this article
79Readers
Mendeley users who have this article in their library.

Abstract

TACI is a TNFR homolog expressed by mature B lymphocytes that has been implicated in the positive regulation of B cell growth and antibody production, as well as in the development of autoimmune disease. Its biology is complex due to the existence of two ligands, BLyS and APRIL, and a homologous receptor, BCMA, that similarly binds both ligands. To determine its critical biological role, we generated TACI knockout mice. Surprisingly, these mice demonstrated a 2-fold increase in numbers of circulating and splenic B cells, apparently due to increased proliferation rate. Maturation of B cells and T-dependent antibody production was normal, but responses to T-independent type II antigens were almost completely abolished. It appears that TACI provides an essential costimulatory signal for the T-independent humoral response.

Cite

CITATION STYLE

APA

Von Bülow, G. U., Van Deursen, J. M., & Bram, R. J. (2001). Regulation of the T-independent humoral response by TACI. Immunity, 14(5), 573–582. https://doi.org/10.1016/S1074-7613(01)00130-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free