Regulatory T cell and forkhead box protein 3 as modulators of immune homeostasis

22Citations
Citations of this article
76Readers
Mendeley users who have this article in their library.

Abstract

The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have addressed and elucidated the role played by FOXP3 and Treg in countless autoimmune and infectious diseases as well as in more specific cases, such as cancer. Within this context, the present article reviews aspects of the immunoregulatory profile of FOXP3 and Treg in the management of immune homeostasis, including issues relating to pathology as well as immune tolerance.

Cite

CITATION STYLE

APA

Pereira, L. M. S., Gomes, S. T. M., Ishak, R., & Vallinoto, A. C. R. (2017, May 26). Regulatory T cell and forkhead box protein 3 as modulators of immune homeostasis. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2017.00605

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free