Whether the red wine component resveratrol directly activates the NAD +-dependent protein deacetylase SIRT1 has been debated. A recent study by Hubbard et al. (2013) strengthens the case that SIRT1-activating compounds (STACs) function as positive allosteric regulators of SIRT1 and thereby regulate mitochondrial function. © 2013 Elsevier Inc.
Gut, P., & Verdin, E. (2013, May 7). Rejuvenating SIRT1 activators. Cell Metabolism. Cell Press. https://doi.org/10.1016/j.cmet.2013.04.016