Relevance of retrovirus quantification in cerebrospinal fluid for neurologic diagnosis

2Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

© 2015 Rosadas and Puccioni-Sohler. Different human retroviruses, such as Human Immunodeficiency Virus (HIV) and Human T-cell Lymphotropic Virus (HTLV), can cause neurologic infection. However, a definitive diagnosis may be hampered by several factors. Quantification of the viral or proviral load in cerebrospinal fluid (CSF) may be helpful in the diagnosis of nervous system disorders due to retroviral infection and may influence the treatment approach. The present work discusses retrovirus infection and neurologic impairment, as well as the usefulness of the determination of the HIV and HTLV proviral or viral load in cerebrospinal fluid in cases of neurologic disorder, in light of recent advances in this field. This study also discusses the different molecular techniques for quantifying the proviral load (real-time quantitative PCR, droplet digital PCR, and semi-nested real-time reverse transcription PCR) that are currently available.

Cite

CITATION STYLE

APA

Rosadas, C., & Puccioni-Sohler, M. (2015, August 8). Relevance of retrovirus quantification in cerebrospinal fluid for neurologic diagnosis. Journal of Biomedical Science. BioMed Central Ltd. https://doi.org/10.1186/s12929-015-0170-y

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free