Chronic inflammation is a characteristic of Alzheimer's disease (AD). An interaction associated with the risk of AD has been reported between polymorphisms in the regulatory regions of the genes for the pro-inflammatory cytokine, interleukin-6 (IL-6, gene: IL6), and the anti-inflammatory cytokine, interleukin-10 (IL-10, gene: IL10).
Combarros, O., van Duijn, C. M., Hammond, N., Belbin, O., Arias-Vásquez, A., Cortina-Borja, M., … Lehmann, D. J. (2009). Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer’s disease. Journal of Neuroinflammation, 6, 22. https://doi.org/10.1186/1742-2094-6-22