Replication-linked histone acetylation in rat liver tissue is sensitive to alkylating agents

5Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.

Abstract

The effect of alkylating agents on histone acetyltransferase (EC 2.3.1.48) activity and thymidine incorporation was investigated in benign and malignant proliferating rat liver tissue and compared with the effect in normal non-proliferating rat liver tissue. In both, benign and malignant proliferating tissue, but not in quiescent tissue, the histone acetylation is depressed by alkylating agents and this depression correlates with the inhibition of the thymidine incorporation. This effect suggests that the depression of the replication associated histone acetylation may be an important factor for the antiproliferative activity of alkylating agents. © 1990.

Cite

CITATION STYLE

APA

Talasz, H., Weiss, G., & Puschendorf, B. (1990). Replication-linked histone acetylation in rat liver tissue is sensitive to alkylating agents. FEBS Letters, 264(1), 141–144. https://doi.org/10.1016/0014-5793(90)80785-H

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free