Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers

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Abstract

Rationale and Objectives: Chronic obstructive pulmonary disease is a heterogeneous disease characterized by small airway abnormality and emphysema. We hypothesized that a voxel-wise computed tomography analytic approach would identify patterns of disease progression in smokers. Materials and Methods: We analyzed 725 smokers in spirometric GOLD stages 0-4 with two chest CTs 5 years apart. Baseline inspiration, follow-up inspiration and follow-up expiration images were spatially registered to baseline expiration so that each voxel had correspondences across all time points and respiratory phases. Voxel-wise Parametric Response Mapping (PRM) was then generated for the baseline and follow-up scans. PRM classifies lung as normal, functional small airway disease (PRM fSAD ), and emphysema (PRM EMPH ). Results: Subjects with low baseline PRM fSAD and PRM EMPH predominantly had an increase in PRM fSAD on follow-up; those with higher baseline PRM fSAD and PRM EMPH mostly had increases in PRM EMPH . For GOLD 0 participants (n = 419), mean 5-year increases in PRM fSAD and PRM EMPH were 0.3% for both; for GOLD 1–4 participants (n = 306), they were 0.6% and 1.6%, respectively. Eighty GOLD 0 subjects (19.1%) had overall radiologic progression (30.0% to PRM fSAD , 52.5% to PRM EMPH , and 17.5% to both); 153 GOLD 1–4 subjects (50.0%) experienced progression (17.6% to PRM fSAD , 48.4% to PRM EMPH , and 34.0% to both). In a multivariable model, both baseline PRM fSAD and PRM EMPH were associated with development of PRM EMPH on follow-up, although this relationship was diminished at higher levels of baseline PRM EMPH . Conclusion: A voxel-wise longitudinal PRM analytic approach can identify patterns of disease progression in smokers with and without chronic obstructive pulmonary disease.

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APA

Labaki, W. W., Gu, T., Murray, S., Hatt, C. R., Galbán, C. J., Ross, B. D., … Han, M. L. K. (2019). Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers. Academic Radiology, 26(3), 306–312. https://doi.org/10.1016/j.acra.2019.02.003

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