Response: CARP1 regulates induction of NF-κB by TNFα

Citations of this article
Mendeley users who have this article in their library.


Tumor necrosis factor α (TNFα)-initiated biological responses are regulated by internalization of the receptor signaling complex and its fusion with components of several endocytic compartments [1]. We have recently reported that CARP2 is constitutively associated with cytosolic membrane vesicles that fuse with the internalized TNF receptor 1 (TNFR1) signaling complex, and that it functions as a ubiquitin protein ligase (E3) for RIP1, an obligate signaling intermediary for NF-κB activation [2]. It has also been shown that CARP2 and its homolog CARP1 function as E3s for caspase-8 and -10, and that knockdown via short hairpin RNAs (shRNAs) of CARP1 or CARP2 expression enhances TNFα-induced caspase activation and cell death [3]. © 2009 Elsevier Ltd. All rights reserved.




Liao, W., Fujita, K. ichi, Xiao, Q., Tchikov, V., Yang, W., Gunsor, M., … Srinivasula, S. M. (2009, January 13). Response: CARP1 regulates induction of NF-κB by TNFα. Current Biology.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free