Tumor necrosis factor α (TNFα)-initiated biological responses are regulated by internalization of the receptor signaling complex and its fusion with components of several endocytic compartments . We have recently reported that CARP2 is constitutively associated with cytosolic membrane vesicles that fuse with the internalized TNF receptor 1 (TNFR1) signaling complex, and that it functions as a ubiquitin protein ligase (E3) for RIP1, an obligate signaling intermediary for NF-κB activation . It has also been shown that CARP2 and its homolog CARP1 function as E3s for caspase-8 and -10, and that knockdown via short hairpin RNAs (shRNAs) of CARP1 or CARP2 expression enhances TNFα-induced caspase activation and cell death . © 2009 Elsevier Ltd. All rights reserved.
Liao, W., Fujita, K. ichi, Xiao, Q., Tchikov, V., Yang, W., Gunsor, M., … Srinivasula, S. M. (2009, January 13). Response: CARP1 regulates induction of NF-κB by TNFα. Current Biology. https://doi.org/10.1016/j.cub.2008.11.041