Retinoid cycle in the vertebrate retina: Experimental approaches and mechanisms of isomerization

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Abstract

Retinoid cycle describes a set of chemical transformations that occur in the photoreceptor and retinal pigment epithelial cells. The hydrophobic and labile nature of the retinoid substrates and the two-cell chromophore utilization-regeneration system imposes significant constraints on the experimental biochemical approaches employed to understand this process. A brief description of the recent developments in the investigation of the retinoid cycle is the current topic, which includes a review of novel results and techniques pertaining to the retinoid cycle. The chemistry of the all-trans-retinol to 11-cis-retinol isomerization is also discussed. © 2003 Elsevier Ltd. All rights reserved.

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Kuksa, V., Imanishi, Y., Batten, M., Palczewski, K., & Moise, A. R. (2003). Retinoid cycle in the vertebrate retina: Experimental approaches and mechanisms of isomerization. Vision Research, 43(28), 2959–2981. https://doi.org/10.1016/S0042-6989(03)00482-6

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