Rev-erbα upregulates NF-κB-responsive genes in vascular smooth muscle cells

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Rev-erbα and retinoic acid receptor-related orphan receptor-α (RORα) are orphan nuclear receptors but their effects on transcription are opposed. Here, we show that Rev-erbα was expressed predominantly in vascular smooth muscle cells (VSMCs) rather than endothelial cells. Overexpression of Rev-erbα upregulated the expression of interleukin-6 and cyclooxygenase-2, and increased transactivation by NF-κB and translocation of p65 to the nucleus in A7r5 VSMCs. Furthermore, the expression of Rev-erbα was upregulated by RORα1 but that upregulation was attenuated by Rev-erbα itself in A7r5 VSMCs. These results suggest a regulatory link between Rev-erbα and the NF-κB pathway. © 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.




Migita, H., Morser, J., & Kawai, K. (2004). Rev-erbα upregulates NF-κB-responsive genes in vascular smooth muscle cells. FEBS Letters, 561(1–3), 69–74.

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