Immune dysregulation is a common problem and immunosenescence plays a major role in the aged population. Many chronic inflammatory diseases have the same effect in the aged such as chronic HIV-treated patients, tuberculosis patients or those with chronic kidney disease. Chronic kidney disease patients have a high incidence of vascular calcification, accelerated atherosclerosis, loss of appetite, increased muscle catabolism, renal osteodystrophy, and a high prevalence of depression because of the dysregulation of the immune system. These patients have different immune system manifestations compared with aged individuals of the same age; moreover, many geriatric syndromes are observed in this group. This review is an analysis from the nephrology perspective on the relationship between chronic kidney disease and the immune system.
Hsu HE, Lang CL, W. M. et. al. (2014). A Review of Chronic Kidney Disease and the Immune System: A Special Form of Immunosenescence. Journal of Gerontology & Geriatric Research, 03(02), 1–6. https://doi.org/10.4172/2167-7182.1000144