A Review of Translational Animal Models for Knee Osteoarthritis

  • Gregory M
  • Capito N
  • Kuroki K
  • et al.
N/ACitations
Citations of this article
269Readers
Mendeley users who have this article in their library.

Abstract

Knee osteoarthritis remains a tremendous public health concern, both in terms of health-related quality of life and financial burden of disease. Translational research is a critical step towards understanding and mitigating the long-term effects of this disease process. Animal models provide practical and clinically relevant ways to study both the natural history and response to treatment of knee osteoarthritis. Many factors including size, cost, and method of inducing osteoarthritis are important considerations for choosing an appropriate animal model. Smaller animals are useful because of their ease of use and cost, while larger animals are advantageous because of their anatomical similarity to humans. This evidence-based review will compare and contrast several different animal models for knee osteoarthritis. Our goal is to inform the clinician about current research models, in order to facilitate the transfer of knowledge from the “bench” to the “bedside.”

Cite

CITATION STYLE

APA

Gregory, M. H., Capito, N., Kuroki, K., Stoker, A. M., Cook, J. L., & Sherman, S. L. (2012). A Review of Translational Animal Models for Knee Osteoarthritis. Arthritis, 2012, 1–14. https://doi.org/10.1155/2012/764621

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free