The crystal structure of trans-resveratrol has been redetermined by X-ray diffraction. The newly refined structure demonstrates that the previously reported, dynamically disordered hydrogen-bonding network is rather the superposition of two crystallographically independent molecules of trans-resveratrol. This latter arrangement possesses a well-defined hydrogen-bonding network in a unit cell of double the previously reported volume. While not meant as a criticism of the proposed antioxidant mechanism itself, the present studies clearly show that the X-ray diffraction data should no longer be used for its additional support.
Zarychta, B., Gianopoulos, C. G., & Pinkerton, A. A. (2016). Revised structure of trans-resveratrol: Implications for its proposed antioxidant mechanism. Bioorganic and Medicinal Chemistry Letters, 26(5), 1416–1418. https://doi.org/10.1016/j.bmcl.2016.01.070