Rhamnogalacturonan from Ilex paraguariensis: A potential adjuvant in sepsis treatment

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Abstract

The present study evaluated the anti-inflammatory activity of a polysaccharide from maté, using a clinically relevant model of sepsis induced by cecal ligation and puncture (CLP). A polysaccharide from maté (SPI) was obtained from aqueous extraction followed by fractionation, being identified as a rhamnogalacturonan with a main chain of →4)-6-OMe-α- d-GalpA-(1→ groups, interrupted by α-l-Rhap units, substituted by a type I arabinogalactan. SPI was tested against induced-polymicrobial sepsis, at doses of 3, 7 and 10 mg/kg. Via oral administration, SPI prevented the late mortality of infected mice by a rate of 60% at 10 mg/kg, in comparison with untreated mice Dexamethasone, used as positive control, was slightly less effective, with an overall survival rate of 16.7% of mice at the end of the observation period. SPI also affected neutrophil influx, avoiding its accumulation in lungs, and significantly decreased tissue expression of iNOS and COX-2. In this context, maté is a potential nutraceutical, and its polysaccharide a promising adjuvant for sepsis treatment, being consumed as tea-like beverages with no related adverse effects. © 2012 Elsevier Ltd.

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Dartora, N., De Souza, L. M., Paiva, S. M. M., Scoparo, C. T., Iacomini, M., Gorin, P. A. J., … Sassaki, G. L. (2013). Rhamnogalacturonan from Ilex paraguariensis: A potential adjuvant in sepsis treatment. Carbohydrate Polymers, 92(2), 1776–1782. https://doi.org/10.1016/j.carbpol.2012.11.013

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